Michael Zasloff Selected Research

24-dihydroxy-5-cholestane 24-sulfate 3-N-1(spermine)-7

1/2022	Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic.
11/2020	Making biological membrane resistant to the toxicity of misfolded protein oligomers: a lesson from trodusquemine.
1/2020	Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism.
1/2018	Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.

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Michael Zasloff Research Topics

Disease

7	Parkinson Disease (Parkinson's Disease) 11/2022 - 01/2017
5	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 01/2020
4	Infections 01/2021 - 04/2006
3	Neuroblastoma 11/2020 - 01/2017
3	Myositis Ossificans (Fibrodysplasia Ossificans Progressiva) 03/2009 - 05/2006
2	Intestinal Failure 01/2021 - 02/2013
2	Alzheimer Disease (Alzheimer's Disease) 01/2020 - 01/2019
2	Constipation 01/2020 - 01/2019
2	Wounds and Injuries (Trauma) 01/2019 - 12/2008
2	Urinary Tract Infections (Urinary Tract Infection) 12/2018 - 11/2007
2	Paralysis (Palsy) 01/2018 - 01/2017
2	Vitamin D Deficiency 11/2008 - 02/2008
2	Neoplasms (Cancer) 02/2008 - 05/2005
1	Graft vs Host Disease (Graft-Versus-Host Disease) 01/2021
1	Nervous System Diseases (Neurological Disorders) 01/2021
1	Proteostasis Deficiencies 01/2020
1	Rare Diseases (Rare Disease) 01/2019
1	Bacterial Infections (Bacterial Infection) 01/2019
1	Infertility (Sterility) 04/2013
1	Crohn Disease (Crohn's Disease) 02/2013
1	Heterotopic Ossification (Ectopic Ossification) 03/2009
1	Ulcer 12/2008
1	Cellulitis 12/2008
1	Foot Ulcer 12/2008
1	Diabetic Foot 12/2008
1	Respiratory Tract Infections (Respiratory Tract Infection) 11/2008
1	Human Influenza (Influenza) 02/2008
1	Communicable Diseases (Infectious Diseases) 02/2008
1	Liver Neoplasms (Liver Cancer) 02/2008
1	Pneumonia (Pneumonitis) 10/2005
1	Peritonitis 10/2005
1	Colonic Neoplasms (Colon Cancer) 05/2005
1	Carcinogenesis 05/2005
1	Retinal Neovascularization 07/2004
1	Hypertrophy 01/2002

Drug/Important Bio-Agent (IBA)

6	squalamineIBA 01/2022 - 01/2002
6	Proteins (Proteins, Gene)FDA Link 01/2021 - 05/2005
6	SynucleinsIBA 01/2021 - 01/2017
4	24-dihydroxy-5-cholestane 24-sulfate 3-N-1(spermine)-7IBA 01/2022 - 01/2018
3	Peptides (Polypeptides)IBA 01/2021 - 04/2013
3	Antimicrobial PeptidesIBA 01/2019 - 06/2006
3	Vitamin D FDA LinkGeneric 02/2008 - 04/2006
2	Amyloid (Amyloid Fibrils)IBA 01/2020 - 01/2019
2	NucleotidesIBA 02/2013 - 05/2008
2	Type I Bone Morphogenetic Protein ReceptorsIBA 03/2009 - 05/2006
2	Serine (L-Serine)FDA Link 03/2009 - 05/2008
2	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 03/2009 - 05/2008
2	Activin Receptors (Activin Receptor)IBA 03/2009 - 05/2008
2	Glycine (Aminoacetic Acid)FDA LinkGeneric 03/2009 - 05/2008
2	Anti-Bacterial Agents (Antibiotics)IBA 12/2008 - 02/2008
2	Transforming Growth Factor beta (TGF-beta)IBA 02/2008 - 05/2005
1	alpha-SynucleinIBA 11/2022
1	NeuropeptidesIBA 01/2021
1	Unilamellar LiposomesIBA 11/2020
1	TabletsIBA 01/2019
1	DefensinsIBA 01/2019
1	AntibodiesIBA 01/2019
1	MagaininsIBA 01/2019
1	CecropinsIBA 01/2019
1	SaltsIBA 01/2019
1	Insulin (Novolin)FDA Link 12/2018
1	Intrinsically Disordered ProteinsIBA 01/2018
1	LipidsIBA 01/2017
1	activin AIBA 03/2009
1	Phosphotransferases (Kinase)IBA 03/2009
1	FluoroquinolonesIBA 12/2008
1	pexigananIBA 12/2008
1	Ofloxacin (Ofloxacine)FDA LinkGeneric 12/2008
1	Anti-Infective Agents (Microbicides)IBA 12/2008
1	Vitamin A (Retinol)FDA LinkGeneric 11/2008
1	Cod Liver OilIBA 11/2008
1	Codon (Codons)IBA 05/2008
1	Interleukin-6 (Interleukin 6)IBA 02/2008
1	CathelicidinsIBA 11/2007
1	plectasinIBA 10/2005
1	SpectrinIBA 05/2005
1	Angiogenesis InhibitorsIBA 07/2004
1	Oxygen (Dioxygen)IBA 07/2004
1	Transferrin (beta 2 Transferrin)IBA 01/2002
1	Collagen Type XIBA 01/2002

Therapy/Procedure

2	Transplantation 01/2021 - 01/2021
2	Therapeutics 01/2019 - 12/2008
1	Parenteral Nutrition 01/2021
1	Surgical Amputation (Amputations) 12/2008